The PhD Programme in Environmental and Health Sciences adopts a transdisciplinary methodological approach to study topics related to human health in connection with environmental factors, the qualitative state of our surroundings, and lifestyle choices. The programme aims to train researchers and professionals with specific expertise in the fields of the promotion of human health and the prevention of diseases. This is achieved through studying and developing innovative solutions from natural plant and animal products, as well as by improving environmental health and protection.
Research projects focus on identifying physiological, cellular, and molecular mechanisms of disease development related to pollutant exposure. They also investigate biomarkers and intracellular pathways relevant to various physio-pathological processes. Moreover, the programme promotes the study of natural and human-made (antropogenic) environmental factors that pose risks to human health and ecosystems. It invites also to develop strategies to protect environmental health, address climate change, and prevent biodiversity loss and the degradation of ecosystem services.
The use of advanced techniques enables the enhancement of diagnostic proficiency for diseases related to environmental exposures and the development of solutions to improve environmental quality. The programme also integrates skills to critically interpret epidemiological data on health status and potential environmental risks for exposed individuals.
Research Topics
Impact of new molecules and innovative therapeutic approaches in inflammation and cancer
Ongoing studies:
Study of antitumor effects of plant extracts derived from agricultural wastes with a view to reuse
Preclinical studies of neo-synthesis molecules (e.g., molecular hybrids) for the treatment of chronic inflammatory diseases and intestinal cancers
Use of 2D and 3D preclinical models to study biological effects of pharmacological inhibitors in solid tumors
Development of organoids for breast cancer and retinoblastoma
Relevant biomarkers in ocular tumors
Research Group Members: Elisabetta Melloni, Mauro Vaccarezza, Rebecca Voltan, Giorgio Zauli
Research Topics
The main activities of the research group involve the study of human remains from mostly archaeological contexts: we study genomic and phenotypic variability in past individuals and its genetic, environmental and/or population causes. We also study their health status, including pathogens and microbiota and their ecological interactions. We use various techniques including osteology, osteometry and molecular archaeanthropology for our studies.
Research Topics
The main activities of the research group involve the study of biomarkers in Alzheimer's disease and other dementias, as well as in metabolic and cardiovascular diseases, exploiting clinical biochemistry and cell biology techniques (in vivo and in vitro study). Our focus is on markers such as beta-secretase 1 (BACE1), ADAM10 and ADAM9, as well as markers of HDL function.
Research Topics
Research topics include plant diversity and mechanisms of functioning in cold climate ecosystems, ecology of plant species of conservation interest, and air quality biomonitoring using wild plant species.
Research Group Members:
Laboratorio di Ecologia vegetale: Renato Gerdol, Lisa Brancaleoni
Research Topics BIOS01/A, General botany
1. Study of the response to environmental pollutants by plant species (especially microalgae) also with a view to phyto-purification;
2. Enhancement of biomass of microalgal species for biotechnological purposes, such as application in agriculture, extraction of molecules of nutra/cosmeceutical interest;
3. Morpho-functional phenotyping of vascular plants of agro-food or evolutionary interest, with particular reference to the photosynthetic apparatus under stress conditions.
Research Group Members:
Prof.ssa Simonetta Pancaldi, dalla Prof.ssa Costanza Baldisserotto e dal Prof. Lorenzo Ferroni.
Research Topics
The organic and industrial chemistry research group deals with the design, synthesis and characterization of innovative molecules and materials of interest to the environment and health, as well as the development of advanced synthetic methodologies.
The analytical, environmental and food chemistry research group is concerned with the development of technologies for environmental restoration, methodologies for chemical monitoring of abiotic and biotic samples also of interest for food safety, and the valorization of wastes and products from the agri-food chain.
Research Group Members
Organic and industrial chemistry: Monica Bertoldo, Graziano Di Carmine, Daniela Perrone
Analytical, environmental and food chemistry: Marco Beccaria, Luisa Pasti, Paola Tedeschi
Research Topics:
The group of ECOLOGY, PARASITOLOGY AND SUSTAINABILITY is engaged in research activities, the majority of which are primarily oriented towards the following fields:
GENERAL AND APPLIED ECOLOGY: The biogeochemistry of fresh and transitional waters and agroecosystems in relation to anthropogenic impacts and global changes, as well as the definition of techniques and strategies for the control of eutrophication (e.g. phytodepuration). The sustainable exploitation of fisheries and aquaculture resources, the protection of endangered fish species, and the control of exotic species are of paramount importance. Furthermore, the estimation, mapping and economic valuation of ecosystem services in aquatic and urban environments is of equal significance.
ECOTOXICOLOGY AND PARASITOLOGY OF AQUATIC ORGANISMS: effects of emerging contaminants (among which PFAS) on fish fauna (bioaccumulation, endocrine disruption), parasitology and immunology of fish, cellular and histological biomarkers of stress.
The following topics are of particular interest within the field of ENVIRONMENTAL AND INDUSTRIAL SUSTAINABILITY:
- industrial fermentation processes for the valorisation of agro-aquaculture and food waste
- biorefineries and bioplastics (e.g. PLA, PHA, PHB)
- development of life cycle assessment (LCA) methods for environmental sustainability assessment in agriculture, aquaculture and industry
Research Topics
Study of the interaction between oxidative stress and inflammation (OxInflammation), both at the physiological and pathological levels in order to understand how redox changes in tissues can lead to an inflammatory response and possibly pathological conditions with focus on skin, gut, lung, and neurodevelopmental diseases (Rett syndrome and autism)
Research Group Members:
Mascia Benedusi, Alessandra Pecorelli, Giuseppe Valacchi
Research Topics
Natural hazards. Power systems of active and extinct volcanoes and pre-eruption timing. Meteorites and impact craters. Wastewater treatment, sustainable agriculture, removal and recycling of N and P from livestock effluents and digestates. Traceability of the agri-food supply chain. Coastal erosion and sedimentation dynamics. Pollution from plastics and microplastics. Critical and strategic raw material sourcing. Aquifer bodies and water-rock interactions. Enhancement and conservation of archaeological and monumental heritage and identification of risk factors.
Research Group Members: Massimo Coltorti, Barbara Faccini, Carmela Vaccaro
Research Topics Hygiene
The main lines of research include (a) quality assessment of scientific evidence; (b) synthesis of evidence on efficacy and safety of vaccines or drugs; (c) predictors of maternal and child health; and (d) quality assessment of health services.
Membri del gruppo di ricerca: Maria Elena Flacco
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Research Topics Occupational Medicine (MEDS-25/B)
Epidemiology of work-related injuries and diseases, in particular, neoplastic, musculoskeletal, respiratory and allergic diseases
Research on the effectiveness of preventive interventions in occupational safety and health
Research on the clinical, immunological and toxicological aspects of occupational and environmental respiratory and allergic diseases
Research Group Members: Stefano Mattioli, Nicola Murgia
Research Topics
Study of the interaction between low-intensity physical activity and chronic lower limb diseases
Research Group Members: Lorenzo Caruso